How DPC Can Help Manage Your Erythema Multiforme

Updated on: September 15, 2025

Erythema Multiforme and Direct Primary Care (DPC): A Quick Fix for a Rash That Keeps Coming Back

 

You suddenly get a rash that looks strange and scary. The spots, which may have started on your hands and feet, look like bullseyes or targets. They are red, sometimes itchy, and you have never seen anything like them before. This is the classic way to show Erythema Multiforme (EM), which is a sudden immune-mediated reaction. Getting a quick, confident diagnosis and finding the root cause are the keys to managing it. The Direct Primary Care (DPC) model is the best way to do this quick and careful evaluation.


 

Comprehending Erythema Multiforme (EM)

 

Erythema Multiforme is a sudden skin reaction that shows up as unique "target lesions." These spots are well-named because they usually have three rings of color around them: a dark or even blistered center, a light middle ring, and a red outer ring.

  • What Makes It Happen?

    • You can't catch EM from someone else. An infection is the most common thing that makes it happen.

    • The #1 Cause: The Herpes Simplex Virus (HSV), which causes cold sores and genital herpes, is the most common cause, accounting for more than half of all cases. The EM rash usually shows up one to two weeks after the herpes outbreak.

    • Other Things That Can Set It Off: Mycoplasma pneumoniae, a bacterium that causes a type of "walking pneumonia," is the second most common infectious trigger. Other infections or some medicines can also cause it, but this is less common.

  • EM is NOT Stevens-Johnson Syndrome (SJS):

    • It is very important for a doctor to tell the difference between Erythema Multiforme and Stevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN), which is a much worse reaction that can kill you and needs to be hospitalized right away. A knowledgeable doctor can tell the difference by looking at the rash and how it spreads, as well as the patient's overall health.


 

How DPC Changes How to Treat Erythema Multiforme

 

Direct Primary Care (DPC) is a membership-based system that lets patients talk to their doctor whenever they want. The DPC model's focus on quick access and a strong diagnostic partnership is a game-changer for a new, worrying rash like EM. DPC is the best choice for this condition for the following reasons:

  1. A quick and correct diagnosis:

    • You want answers right away when you get a new rash.

    • Access on the Same Day: Your DPC doctor can see you right away, usually the same day you call, to look at the rash.

    • Expert Clinical Diagnosis: DPC's long, relaxed appointments give the skin a full checkup. Your doctor can tell what the classic target lesions are and, by asking questions about your past, can often figure out what caused them (for example, "Did you have a cold sore on your lip a couple of weeks ago?").

    • Right away, you can feel better: This quick and sure diagnosis lets your doctor reassure you right away by explaining what the rash is and how it is different from more serious conditions like SJS.

  2. Helping the patient and treating the trigger:

    • After your DPC doctor makes a diagnosis, they can start a clear plan.

    • Care that helps: Most people with mild EM get supportive care. For the spots, your doctor can give you topical corticosteroids and oral antihistamines to help with the itching and pain.

    • Finding the Cause: If you have an active HSV infection or if Mycoplasma pneumonia is the cause, your doctor can give you the right antiviral or antibiotic medicine.

  3. A Plan for Recurrent EM That Is Proactive:

    • This is where DPC's consistency really shines. A lot of people who get EM once will get it again, especially if it happens because of HSV that keeps coming back.

    • A Strategy to Prevent: Your DPC doctor can give you daily antiviral therapy to keep the virus from spreading. Taking a small amount of an antiviral drug like acyclovir or valacyclovir every day is a very good way to stop HSV outbreaks and, in turn, stop future episodes of the painful EM rash.

    • Partnership for a Long Time: DPC gives the close, ongoing follow-up that is necessary to safely and effectively manage this long-term preventive therapy.


 

True Stories of Success

 

  • Case 1: Jessica, 28, gets a rash all over her body with classic target lesions on her hands and feet about ten days after getting a cold sore. That day, she sees her DPC doctor. The doctor quickly identifies it as classic HSV-associated Erythema Multiforme, which is not a dangerous condition. He then prescribes a topical steroid to help with the itching. The rash goes away completely in the next two weeks.

  • Case 2: David, 35, has had three terrible cases of Erythema Multiforme in the last year, and each one came after an outbreak of genital herpes. He is sick of the painful and debilitating rashes that keep him from going to work. His DPC doctor talks to him for a long time about how to prevent the disease and gives him a daily dose of valacyclovir to keep it from getting worse. David has not had an outbreak of either herpes or Erythema Multiforme in the year since his last visit.


 

Questions and Answers: Erythema Multiforme and Direct Primary Care (DPC)

 

  • Q: Can you get Erythema Multiforme from someone else?

    • A: No. The rash is a reaction of your immune system that happens inside your body and isn't contagious. But the infection that caused the rash, like the Herpes Simplex Virus, can spread through direct contact with the sores.

  • Q: I get cold sores a lot. Does that mean I'm going to get this rash?

    • A: Not always. Only a limited group of individuals infected with the HSV virus will exhibit the particular immune response that results in Erythema Multiforme. It is a reaction that is different for each person. If you do get the rash after a cold sore, though, you are very likely to get it again with other cold sores.

  • Q: Do I need to go to a dermatologist for this rash?

    • A: Your DPC doctor can accurately diagnose and treat most cases of uncomplicated Erythema Multiforme. If the diagnosis is unclear, the case is unusually severe (for example, if there are a lot of blisters or mouth sores that make it hard to eat or drink), or if you aren't responding to standard treatments, they will set up a referral to a dermatologist.


 

Why DPC Is Good for People with Erythema Multiforme

 

DPC has a clear advantage for this reactive rash because:

  • Giving a quick and correct diagnosis: DPC's same-day access and time for a full exam are important for correctly identifying the classic target lesions and telling EM apart from more serious rashes.

  • Doing a great job of managing a disease that keeps coming back: The DPC model is perfect for handling long-term, daily antiviral therapy that can stop episodes from coming back and making people sick.

  • Giving people peace of mind and keeping them from going to the emergency room when they don't need to: A trusted DPC doctor's confident clinical diagnosis can give you peace of mind right away and keep you out of the crowded and expensive emergency room.

A rash that spreads quickly is always scary. But the classic target lesions of Erythema Multiforme tell a specific story—usually of a recent infection that has triggered an immune response. You need a medical partner who can see you right away, understand the signs, and make a plan for both short-term relief and long-term prevention. Direct Primary Care gives you quick access and ongoing support to confidently and expertly deal with this reactive rash.

Published on: November 13, 2024
Doctors that manage erythema multiforme
  • Christopher Gonzalez, Concierge Family Medicine in Long Island
    Christopher Gonzalez, DO
    Concierge Family Medicine
    Long Island, New York
    Monthly Subscription Fee: Info Unavailable
    Max Patient In Panel: Info Unavailable
    Telehealth - Pending
    Home Visit - Pending
    Holistic/Lifestyle Med - Pending
    Dr. Gonzalez is fantastic. He is pleasant and attentive. He seemed eager to give me all the time I needed and to answer all of my questions.
  • Daniel Silvershein, Concierge Internal Medicine in New York
    Daniel Silvershein, MD
    Concierge Internal Medicine
    New York, New York
    Monthly Subscription Fee: Info Unavailable
    Max Patient In Panel: Info Unavailable
    Telehealth - Pending
    Home Visit - Pending
    Holistic/Lifestyle Med - Pending
    A wonderful internist who brings a skill set to the patient often not seen in doctors these days. Dr. Silvershein is exceptional because he is sensitive and has excellent listening skills. He stands out!!
  • Shanna Levine, Concierge Internal Medicine in New York
    Shanna Levine, MD
    Concierge Internal Medicine
    New York, New York
    Monthly Subscription Fee: Info Unavailable
    Max Patient In Panel: Info Unavailable
    Telehealth - Pending
    Home Visit - Pending
    Holistic/Lifestyle Med - Pending
    I was able to get direct answers to all of my questions. She was extremely patient with me. She gave me all the time I needed with her and was always available to address all my concerns.
  • Ellen Wexler, Concierge Internal Medicine in New York
    Ellen Wexler, MD
    Concierge Internal Medicine
    New York, New York
    Monthly Subscription Fee: Info Unavailable
    Max Patient In Panel: Info Unavailable
    Telehealth - Pending
    Home Visit - Pending
    Holistic/Lifestyle Med - Pending
    I'm the best version of myself, both physically and mentally. She takes the time to learn about your condition and explain how to overcome it.
  • Andrew Kelly, Concierge Family Medicine in New York
    Andrew Kelly, PA
    Concierge Family Medicine
    New York, New York
    Monthly Subscription Fee: Info Unavailable
    Max Patient In Panel: Info Unavailable
    Telehealth - Pending
    Home Visit - Pending
    Holistic/Lifestyle Med - Pending
    Dr. Kelly examined the entire picture and asked probing questions to have a better grasp of what was wrong with me. 
  • Lorraine Sanassi, Concierge Family Medicine in New York
    Lorraine Sanassi, PA-C
    Concierge Family Medicine
    New York, New York
    Monthly Subscription Fee: Info Unavailable
    Max Patient In Panel: Info Unavailable
    Telehealth - Pending
    Home Visit - Pending
    Holistic/Lifestyle Med - Pending
    I can see the sincerity and utmost care in her actions
  • Miral Vaghasia, Concierge Family Medicine in New York
    Miral Vaghasia, DO
    Concierge Family Medicine
    New York, New York
    Monthly Subscription Fee: Info Unavailable
    Max Patient In Panel: Info Unavailable
    Telehealth - Pending
    Home Visit - Pending
    Holistic/Lifestyle Med - Pending
    Takes into account the entirety of a person. Genuine and comprehensive. Highly Recommended!
  • Jessica Rosenberg, Concierge Family Medicine in New York
    Jessica Rosenberg, DO
    Concierge Family Medicine
    New York, New York
    Monthly Subscription Fee: Info Unavailable
    Max Patient In Panel: Info Unavailable
    Telehealth - Pending
    Home Visit - Pending
    Holistic/Lifestyle Med - Pending
    Dr. Rosenberg is patient, thorough, and very knowledgeable with excellent bed side manner. She took her time to discuss multiple treatment options and make you feel at ease.